4 years ago

[ASAP] Identification of a Strigoterpenoid with Dual Nrf2 and Nf-?B Modulatory Activity

[ASAP] Identification of a Strigoterpenoid with Dual Nrf2 and Nf-?B Modulatory Activity
Federica Rogati, Estrella Millán, Giovanni Appendino, Alejandro Correa, Diego Caprioglio, Alberto Minassi, Eduardo Muñoz
The sesquiterpene–coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A–C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

Publisher URL: http://dx.doi.org/10.1021/acsmedchemlett.8b00604

DOI: 10.1021/acsmedchemlett.8b00604

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