3 years ago

Chichibabin pyridinium synthesis

Akiho Imura, Nao Tanaka, Toyonobu Usuki

Publication date: Available online 8 January 2019

Source: Tetrahedron Letters

Author(s): Akiho Imura, Nao Tanaka, Toyonobu Usuki


Chichibabin pyridine synthesis involves the reaction of three aldehydes and ammonia to form 2,3,5-trisubstituted pyridines. This study examined the synthesis of tetrasubstituted pyridinium from aldehydes and an amine hydrochloride in the presence/absence of Pr(OTf)3. Important insights into the reaction mechanisms of Chichibabin pyridinium synthesis were proposed through the investigation of reaction intermediates along with quantitative GC-MS analysis.

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