3 years ago

PD-1 Up-regulation is Associated with Exhaustion of Regulatory T Cells and Reflects Immune Activation in HIV-1 Infected Individuals.

Jian Xiao, Lifeng Zhang, Yuan Dong, Xian Liu, Lishan Peng, Yang Yang, Ying Wang
We hypothesized that PD-1expressed by regulatory T cells (Tregs) would be functional and their expression levels may associate with activation status of CD4+ T, CD8+ T cells and the disease progression of HIV-1 infected patients. In order to prove it, we dynamically examined PD-1 expression levels by Tregs in peripheral blood of HIV-1 infected individuals not receiving anti-retro viral therapy.

Publisher URL: http://doi.org/10.1089/AID.2018.0218

DOI: 10.1089/AID.2018.0218

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