3 years ago

HIV status does not affect rectal microbiome composition, diversity or stability over time: A Chicago Women's Interagency HIV Study (WIHS).

Brett Williams, Kathleen M Weber, George Chlipala, Charlesnika Evans, Ralph Morack, Audrey French
It remains unclear whether differences in gut microbiota noted between HIV infected and uninfected individuals are driven by HIV or sexual behavior. We evaluated rectal swab microbiota of HIV-infected and uninfected women with similar demographic, neighborhood and diet characteristics enrolled in the Chicago Women's Interagency HIV Study (WIHS). DNA was amplified for sequencing of fragments of bacterial small subunit (SSU or 16S) ribosomal RNA (rRNA) genes. HIV infected and uninfected women did not differ by Shannon diversity index (p=0.14), NMDS plot of Bray-Curtis indices (p=0.488, r=0.0027) or copy number of individual taxa. Both groups demonstrated marked microbiome stability over time (p=0.889).

Publisher URL: http://doi.org/10.1089/AID.2018.0250

DOI: 10.1089/AID.2018.0250

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