3 years ago

Sex differences in [ 11 C]ABP688 binding: a positron emission tomography study of mGlu5 receptors

Kelly Smart, Sylvia M. L. Cox, Stephanie G. Scala, Maria Tippler, Natalia Jaworska, Michel Boivin, Jean R. Séguin, Chawki Benkelfat, Marco Leyton

Abstract

Purpose

The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [11C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor.

Methods

High resolution [11C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Mean binding potential (BPND = fND * (Bavail / KD)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region.

Results

[11C]ABP688 BPND was significantly higher in men compared to women in the prefrontal cortex (p < 0.01), striatum (p < 0.001), and hippocampus (p < 0.05). Whole-brain BPND was 17% higher in men. BPND was not related to menstrual phase in women.

Conclusions

Binding availability of mGlu5 receptors as measured by PET [11C]ABP688 is higher in healthy men than women. This likely represents a source of variability in [11C]ABP688 studies and could have relevance for sex differences in cognitive-behavioral functions and neuropsychiatric disorders.

Publisher URL: https://link.springer.com/article/10.1007/s00259-018-4252-4

DOI: 10.1007/s00259-018-4252-4

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