3 years ago

IMRT‐based treatment of unknown primary malignancy of the head and neck: Outcomes and improved toxicity with decreased mucosal dose and larynx sparing

Anna W. LaVigne, Danielle N. Margalit, Bhupendra Rawal, Maria Puzanov, Donald J. Annino, Laura A. Goguen, David J. Sher, Jonathan D. Schoenfeld, Nicole G. Chau, Jochen H. Lorch, Guilherme Rabinowits, Robert I. Haddad, Roy B. Tishler

Abstract

Background

Radiation therapy for squamous cell cancer of the head and neck with unknown primary (head and neck CUP) has been associated with significant levels of swallowing toxicity. We examined the effect of changes in mucosal dose on development of laryngeal strictures and percutaneous endoscopic gastrostomy (PEG) dependence.

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