3 years ago

Acute myeloid leukemia with t(10;11)(p11‐12;q23.3): Results of Russian Pediatric AML registration study

Elena Zerkalenkova, Svetlana Lebedeva, Anna Kazakova, Grigory Tsaur, Yulia Starichkova, Natalia Timofeeva, Olga Soldatkina, Evgenia Aprelova, Aleksandr Popov, Natalia Ponomareva, Ludmila Baidun, Claus Meyer, Galina Novichkova, Michael Maschan, Aleksey Maschan, Rolf Marschalek, Yulia Olshanskaya

Abstract

Introduction

Translocations involving the KMT2A gene (also known as MLL) are frequently diagnosed in pediatric acute leukemia cases with either lymphoblastic or myeloid origin. KMT2A is translocated to multiple partner genes, including MLLT10/AF10 localizing at chromosomal band 10p12. KMT2A‐MLLT10 is one of the common chimeric genes diagnosed in acute leukemia with KMT2A rearrangement (8%), especially in acute myeloid leukemia (AML; 18%). MLLT10 is localized in very close proximity to two other KMT2A partner genes at 10p11‐12—NEBL and ABI1, so they could not be distinguished by conventional cytogenetics.

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