3 years ago

Paraherquamide J, a new prenylated indole alkaloid from the marine-derived fungus Penicillium janthinellum HK1-6

Paraherquamide J, a new prenylated indole alkaloid from the marine-derived fungus Penicillium janthinellum HK1-6
Yao-Yao Zheng, Nan-Xing Shen, Zhao-Yang Liang, Li Shen, Min Chen, Chang-Yun Wang
A new prenylated indole alkaloid, named paraherquamide J (1), together with four known compounds (25), were isolated from the mangrove rhizosphere soil-derived fungus Penicillium janthinellum HK1-6. The planar structure and relative configuration of 1 were determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. The absolute configuration of 1 was determined by ECD spectra. Compound 2 was first isolated as a natural product and named as paraherquamide K. All isolated metabolites were evaluated for their antibacterial, topoisomerase I (topo I) inhibitory activities and lethality towards brine shrimp Artemia salina.

Publisher URL: https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1534105

DOI: 10.1080/14786419.2018.1534105

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