Ruthenium(II)-Catalyzed Indolo[2,1-a]isoquinolines Synthesis by Tandem C–H Allylation and Oxidative Cyclization of 2-Phenylindoles with Allyl Carbonates

5 years ago

Ruthenium(II)-Catalyzed Indolo[2,1-a]isoquinolines Synthesis by Tandem C–H Allylation and Oxidative Cyclization of 2-Phenylindoles with Allyl Carbonates

Lin Dong, Ying-Qi Xia

A novel Ru^II-catalyzed tandem C–H bond activation tool has been successfully developed involving allylation and oxidative cyclization of 2-phenyl indoles with allyl carbonates. This one-pot reaction is a new way to synthesize indolo[2,1-a]isoquinoline units via a simple and efficient process.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00762

DOI: 10.1021/acs.orglett.7b00762

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