5 years ago

Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model

Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model
Christian Wiraja, Jinmin Zhao, Chenjie Xu, Jinlu Zhang, Li Zheng, Pan Jin
Osteoarthritis (OA) is a chronic arthritic disease that causes the overproduction of inflammatory factors such as nitric oxide (NO). This study develops a NO nanosensor to predict the OA development. The nanosensor is synthesized by encapsulating the NO sensing molecules (i.e., 4-amino-5-methylamino-2′,7′-difluorofluorescein Diaminofluorescein-FM (DAF-FM)) within the biodegradable poly(lactic-co-glycolic acid) nanoparticles. In vitro, the nanosensor allows the monitoring of the NO release in interleukin-1β-stimulated chondrocytes and the alleviated effect of NG-monomethyl-l-arginine (a NO inhibitor) and andrographolide (an anti-inflammatory agent). In the rat OA model, it permits the quantification of NO level in joint fluid. The proposed NO nanosensor may facilitate a noninvasive and real-time evaluation of the OA development.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b06404

DOI: 10.1021/acsami.7b06404

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