Analytical Chemistry
Analytical Chemistry
5 years ago

Optical pH Sensor Covering the Range from pH 0–14 Compatible with Mobile-Device Readout and Based on a Set of Rationally Designed Indicator Dyes

Optical pH Sensor Covering the Range from pH 0–14 Compatible with Mobile-Device Readout and Based on a Set of Rationally Designed Indicator Dyes
Knut Rurack, Mandy Hecht, Pichandi Ashokkumar, Raúl Gotor, Karin Keil
In this work, a family of pH-responsive fluorescent probes has been designed in a rational manner with the aid of quantum chemistry tools, covering the entire pH range from 0–14. Relying on the boron–dipyrromethene (BODIPY) core, all the probes as well as selected reference dyes display very similar spectroscopic properties with ON–OFF fluorescence switching responses, facilitating optical readout in simple devices used for detection and analysis. Embedding of the probes and reference dyes into hydrogel spots on a plastic strip yielded a test strip that reversibly indicates pH with a considerably small uncertainty of ∼0.1 pH units. These strips are not only reusable but, combined with a 3D-printed case that can be attached to a smartphone, the USB port of which drives the integrated LED used for excitation, allows for autonomous operation in on-site or in-the-field applications; the developed Android application software (“app”) further simplifies operation for unskilled users.

Publisher URL: http://dx.doi.org/10.1021/acs.analchem.7b01903

DOI: 10.1021/acs.analchem.7b01903

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