3 years ago

Diastereo- and Enantioselective Synthesis of 2,2-Disubstituted Benzofuran-3-one Bearing Adjacent Quaternary and Tertiary Stereocenters

Diastereo- and Enantioselective Synthesis of 2,2-Disubstituted Benzofuran-3-one Bearing Adjacent Quaternary and Tertiary Stereocenters
Venkitasamy Kesavan, Nandarapu Kumarswamyreddy, Koilpitchai Sivamuthuraman
The first highly diastereo- and enantioselective synthesis of armeniaspirol analogues was achieved using L-proline derived bifunctional squaramide which outperformed commonly used organocatalysts. Excellent yield (up to 99%) with diastereoselectivity (up to 99:1) and enantioselectivity (up to 99%) were obtained for a wide range of substrates.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01105

DOI: 10.1021/acs.joc.7b01105

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