3 years ago

Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles

Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles
Kezhou Wang, Haiyong Zhu, Dan Li, Linqing Wang, Rui Wang, Yuyang Liu, Xihong Liu, Dongxu Yang, Pengxin Wang
A magnesium catalyzed asymmetric conjugate reaction of C3-pyrrolyl-oxindoles with terminal alkynones is presented. The current asymmetric conjugate reaction relies on the development of novel combinational magnesium catalysis involving two chiral ligands. The current protocol proceeds smoothly and gives the corresponding enantioenriched 3,3-disubstituted oxindole skeletons with good enantioselectivities. Furthermore, the conjugate adducts could be transferred to spiro oxindole structures containing an eight-membered ring in high ee values.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02044

DOI: 10.1021/acs.orglett.7b02044

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