5 years ago

Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants

Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants
Zhiyuan Ma, Meng Zhang, X. X. Zhu, Qixuan Yu, Yong-Guang Jia
Acrylamide derivatives of bile acids are chosen as a hydrophobic comonomer to copolymerize with acrylamide via reversible addition and fragmentation chain transfer (RAFT) polymerization to afford a series of copolymers of P(AAm-co-CAA). These copolymers exhibit a sharp and reversible insoluble–soluble transition in water upon heating to a mixing temperature (Tmix) related to the upper critical solution temperature (UCST). Tmix of these copolymers can be conveniently tuned to a practical temperature range, around 37 °C for biomedical applications. Tmix rises with increasing molar fraction of the bile acid-based acrylamide and increasing concentration of the aqueous solution of the copolymers. The addition of a natural host molecule β-cyclodextrin lowered the Tmix. The insoluble–soluble transition of the copolymers was also evidenced by dynamic light scattering and transmission electron microscopy. The biocompatible nature of the bile acids and β-cyclodextrins may make these copolymers potentially useful for biomedical applications.

Publisher URL: http://dx.doi.org/10.1021/acs.biomac.7b00860

DOI: 10.1021/acs.biomac.7b00860

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