Organic Letters
Organic Letters
5 years ago

Ralstonins A and B, Lipopeptides with Chlamydospore-Inducing and Phytotoxic Activities from the Plant Pathogen Ralstonia solanacearum

Ralstonins A and B, Lipopeptides with Chlamydospore-Inducing and Phytotoxic Activities from the Plant Pathogen Ralstonia solanacearum
Yasufumi Hikichi, Yuta Murai, Kenji Kai, Hiroyuki Konno, Shoko Mori
Ralstonia solanacearum has an orphan hybrid polyketide synthase-nonribosomal peptide synthetase gene cluster. We herein isolate its products (named ralstonins A and B) from R. solanacearum and elucidate their structures and biological activities. Ralstonins are unusual lipodepsipeptides composed of 11 amino acids (containing unique amino acids such as β-hydroxytyrosine and dehydroalanine) and a 3-amino-2-hydroxyoctadecanoic acid, and their production is controlled by quorum sensing, a mechanism of bacterial cell–cell communication. Ralstonins exhibited chlamydospore-inducing activity and phytotoxicity.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01685

DOI: 10.1021/acs.orglett.7b01685

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