Chemical Engineering Journal
Chemical Engineering Journal
4 years ago

Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery

Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery
Constructing smart nano-systems for intracellular delivery of functional proteins has been endeavored for diverse biomedical applications, but suffered daunting challenges. Herein silica nanospheres entrapped with photoluminescent CaF2:Tm,Yb nanocrystals were synthesized and decorated with amino molecules for protein delivery. Amino-modified nanospheres presented high protein loading capacity and sustained release phenomenon. The photoluminescence of particles highly corresponded to protein release progress. The preliminary in-vitro study confirmed markedly enhanced cell up-taking efficiency of protein molecules with the nanocomposite developed.

Publisher URL: www.sciencedirect.com/science

DOI: S1385894717312202

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