3 years ago

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes
Joice Thomas, Sampad Jana, Sandra Liekens, Jan Balzarini, Wim Dehaen, Mahendra Sonawane, Bert Fiey
A Gewald-four component reaction has been successfully developed for the synthesis of a series of compounds containing an indole and a 2-aminothiophene moiety separated by a methylene spacer having anti-proliferative activity.

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/_2dYMEB4hJ0/C7OB00707H

DOI: 2017/OB/C7OB00707H

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