3 years ago

Mild Cobalt(III)-Catalyzed Allylative C−F/C−H Functionalizations at Room Temperature

Mild Cobalt(III)-Catalyzed Allylative C−F/C−H Functionalizations at Room Temperature
Stefan Grimme, Rubén Rubio Presa, Markus Bursch, Lutz Ackermann, Uttam Dhawa, Valentin Müller, Daniel Zell
Sustainable, cobalt-catalyst enabled, synthetically significant C−F/C−H functionalizations were achieved with an ample substrate scope at an ambient temperature of 25 °C, thereby delivering perfluoroallylated heteroarenes. Detailed experimental and computational mechanistic studies on the C−F/C−H functionalizations provided strong support for a facile C−F cleavage. Refreshingly mild: Versatile cobalt-catalyzed C−F/C−H functionalizations were achieved under exceedingly mild reaction conditions at 25 °C through facile C−F cleavage.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702528

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