Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Luminescent Zinc Fingers: Zn-Responsive Neodymium Near-Infrared Emission in Water

Luminescent Zinc Fingers: Zn-Responsive Neodymium Near-Infrared Emission in Water
Didier Boturyn, Manon Isaac, Olivier Sénèque, Stéphane Petoud, Céline Cepeda, Svetlana V. Eliseeva, Amandine Roux, Laurent Raibaut
Responsive luminescent probes emitting in the near-infrared (NIR) are in high demand today for biological applications as they allow for the easy and unambiguous discrimination of autofluorescence. Due to their luminescence properties, lanthanide ions offer an interesting alternative to classical organic fluorescent dyes. This has stimulated the development of lanthanide-based responsive probes. Nevertheless, responsive probes that can operate in water with NIR-emitting lanthanide ions are scarce. In this communication, zinc fingers are shown to be versatile scaffolds to elaborate a variety of Zn2+-responsive probes based on lanthanide emission and featuring desirable properties for the selective detection of Zn2+ in experimental conditions close to cellular. Of special interest is a NIR-emitting probe relying on Nd3+ emission. Lighting neodymium with zinc: A family of lanthanide-based probes elaborated on a zinc finger peptide scaffold shows a selective turn-on emission response to Zn2+ in pseudo-physiological conditions. One of these probes is able to report the presence of Zn2+ by the near-infrared emission of neodymium at 1060 nm.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201703089

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.