5 years ago

Preparation of Spiro[indene-1,1′-isoindolin]-3′-ones via Sulfuric Acid-Promoted Cascade Cyclization

Preparation of Spiro[indene-1,1′-isoindolin]-3′-ones via Sulfuric Acid-Promoted Cascade Cyclization
Jing Wang, Ping Lu, Peng Liu, Lang Sun, Yanguang Wang
The sulfuric acid-promoted cascade cyclization of 2-(3-hydroxyprop-1-ynyl)benzonitriles led to an efficient synthesis of spiro[indene-1,1′-isoindolin]-3′-ones. This class of spiro compounds could also be prepared by the sulfuric acid-catalyzed cyclization of 2-(phenylacryloyl)benzonitriles, which were readily derived from 2-(3-hydroxyprop-1-ynyl)benzamides using trifluoroacetic acid as a catalyst.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00958

DOI: 10.1021/acs.joc.7b00958

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