5 years ago

Nature-Inspired Construction of Two-Dimensionally Self-Assembled Peptide on Pristine Graphene

Nature-Inspired Construction of Two-Dimensionally Self-Assembled Peptide on Pristine Graphene
Kook-Han Kim, Bumjoon Choi, Nam Hyeong Kim, Bramaramba Gnapareddy, Young Hyun No, Seungwoo Lee, Young-Seon Ko, Yong-Tae Kim, Sung Ha Park, Sang Woo Lee, Sreekantha Reddy Dugasani, Yong Ho Kim, One-Sun Lee, Kilho Eom
Peptide assemblies have received significant attention because of their important role in biology and applications in bionanotechnology. Despite recent efforts to elucidate the principles of peptide self-assembly for developing novel functional devices, peptide self-assembly on two-dimensional nanomaterials has remained challenging. Here, we report nature-inspired two-dimensional peptide self-assembly on pristine graphene via optimization of peptide–peptide and peptide–graphene interactions. Two-dimensional peptide self-assembly was designed based on statistical analyses of >104 protein structures existing in nature and atomistic simulation-based structure predictions. We characterized the structures and surface properties of the self-assembled peptide formed on pristine graphene. Our study provides insights into the formation of peptide assemblies coupled with two-dimensional nanomaterials for further development of nanobiocomposite devices.

Publisher URL: http://dx.doi.org/10.1021/acs.jpclett.7b00996

DOI: 10.1021/acs.jpclett.7b00996

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