ACS Catalysis
ACS Catalysis
4 years ago

A Generalized Picture of C–C Cross-Coupling

A Generalized Picture of C–C Cross-Coupling
Matthew D. Wodrich, Clémence Corminboeuf, Michael Busch
Transition metal catalyzed cross-coupling reactions occupy a privileged position in chemistry because of their ability to link myriad functional groups. The numerous variants of this class of reactions (e.g., Suzuki, Kumada, Negishi, etc.) differ in the transmetalation agent used to transfer “R” groups onto the catalyst. While understanding any single variant (e.g., Suzuki coupling) can be accomplished through direct analysis of the catalytic cycle, a comprehensive picture that illustrates the interrelationships between the different types of cross-coupling reactions remains absent. Here, using a tool built upon a three-dimensional volcano plot, we create a generalized thermodynamic picture of C–C cross-coupling reactions. This “cross-coupling” genome not only facilitates better understanding of catalytic behavior but also outlines strategies for developing new reaction protocols through the manipulation of easily computed descriptor variables.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b01415

DOI: 10.1021/acscatal.7b01415

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.