Inorganic Chemistry
Inorganic Chemistry
5 years ago

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes
Emilia Păunescu, Paul J. Dyson, Rosario Scopelliti, Lucinda K. Batchelor, Mylène Soudani
The impact of the multinuclearity, lipophilicity, and linker length on the antiproliferative activity of two novel series of phosphine-linked dinuclear ruthenium(II) p-cymene and gold(I) organometallic complexes on tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK-293) cell lines was assessed. The dinuclear ruthenium(II) complexes were considerably more cytotoxic than their mononuclear counterparts, and a correlation between the lipophilicity of the linker and the cytotoxicity was observed, whereas the cytotoxicity of the gold(I) series is independent of these factors.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01082

DOI: 10.1021/acs.inorgchem.7b01082

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