3 years ago

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)
Pascal Retailleau, Armen Panossian, Guillaume Levitre, Géraldine Masson, Audrey Dumoulin, Frédéric R. Leroux
An enantioselective direct oxygenation of propiophenone derivatives mediated by a catalytic or stoichiometric amount of new chiral non-C2-symmetric iodoarenes(III) is reported. The reaction gives an easy entry to optically active α-sulfonyl- and α-phosphoryl oxyketones in respectable yields and enantioselectivities.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01597

DOI: 10.1021/acs.joc.7b01597

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