3 years ago

Route to Substituted Furan-2(5H)-ones from cyclo-Alkenecarboxylic Acids and Acrylates via C–H Activation

Route to Substituted Furan-2(5H)-ones from cyclo-Alkenecarboxylic Acids and Acrylates via C–H Activation
Kun Zhu, Man Li, Jing-Li He, Jun-Xian Li, Ting-Feng Han, You-Quan Zhu
Under rhodium(III) catalysis, four kinds of cycloalkenecarboxylic acids successfully reacted with acrylates via direct activation of the β-alkenyl C–H bond. The present protocol provides the facile and highly efficient synthesis of substituted furan-2(5H)-ones from readily available starting materials with moderate to good yields. In addition, their possible reaction mechanisms were also discussed.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01423

DOI: 10.1021/acs.joc.7b01423

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