3 years ago

Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells [Engineering]

Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells [Engineering]
Adam R. Abate, Christian A. Siltanen, Zev J. Gartner, Payam Shahi, Russell H. Cole, Shi-Yang Tang, Sean Poust, Jesse Q. Zhang

Although the elementary unit of biology is the cell, high-throughput methods for the microscale manipulation of cells and reagents are limited. The existing options either are slow, lack single-cell specificity, or use fluid volumes out of scale with those of cells. Here we present printed droplet microfluidics, a technology to dispense picoliter droplets and cells with deterministic control. The core technology is a fluorescence-activated droplet sorter coupled to a specialized substrate that together act as a picoliter droplet and single-cell printer, enabling high-throughput generation of intricate arrays of droplets, cells, and microparticles. Printed droplet microfluidics provides a programmable and robust technology to construct arrays of defined cell and reagent combinations and to integrate multiple measurement modalities together in a single assay.

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