Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells

Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells
Xiaogang Qu, Jinsong Ren, Faming Wang, Jiasi Wang, Hongshuang Qin
Telomerase is a key regulator in cell metabolism, tissue renewal, and organismal lifespan. Here we develop a simple strategy to modulate cellular telomerase activity, and further control cell fate based on Mg2+- and Zn2+-activated DNAzymes in living cells. Through modulation of telomerase activity, we can regulate cell behavior, including cell migration, cell differentiation, cell senescence, and cell cycle. Our work provides a new way to modulate telomerase activity in living cells by using DNAzymes. Cell fate: A simple and new strategy to modulate telomerase activity in living cells has been developed based on metal-ion-activated DNAzymes (see scheme). This assay can be further used for control of cell fate. Through modulation of telomerase activity, cellular behavior can be regulated, including cell migration, cell differentiation, cell senescence, and cell cycle.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702236

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