Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Inside Back Cover: 2′β-Fluoro-Tricyclo Nucleic Acids (2′F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation (Chem. Eur. J. 43/2017)

Inside Back Cover: 2′β-Fluoro-Tricyclo Nucleic Acids (2′F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation (Chem. Eur. J. 43/2017)
Adam Katolik, Alena Istrate, Christian J. Leumann, Andrei Istrate
What a difference a fluorine makes when introduced into the 2′-β-position of the tricyclo-DNA skeleton (2′F-tc-ANA). It steers the conformation of the furanose unit into an eastern conformation. Fully modified 2′F-tc-ANA shows enhanced binding to complementary RNA in the same way as parent tc-DNA. Embedded in a 2′OMe-RNA hybrid construct it enables RNaseH cleavage of a complementary RNA target, thus enhancing the application range of the tc-DNA family as antisense agents. More information can be found in the Full Paper by C. J. Leumann et al. on page 10310.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702636

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