ChemBioChem
ChemBioChem
5 years ago

Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement

Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement
Hiroyuki Asanuma, Atsushi Maruyama, Hiromu Kashida, Bohao Cheng, Naohiko Shimada
The cover picture shows how a reversible DNA-strand-displacement system is photoregulated, and assisted by a chaperon polymer, PLL-g-Dex. With visible light irradiation, a strand incorporated with azobenzene moieties (in the trans form) can hybridize its complementary strand and release another without any toehold domain; with UV irradiation, these azobenzenes (in the cis form) devastatingly destabilize the duplex, resulting in reversed strand displacement. This clean and reversible light-driven process subverts these defects in classical toehold strand displacement and is expected to bring in a new tool in nucleic acid isothermal amplification and DNA nanotechnology. More information can be found in the communication by A. Maruyama, H. Asanuma, et al. (DOI: 10.1002/cbic.201700202).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700394

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