Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization

Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization
Thomas Theis, Kun Shen, Angus W. J. Logan, Qiu Wang, Warren S. Warren, Steven J. Malcolmson, Johannes F. P. Colell, Gerardo X. Ortiz, Junu Bae
Diazirines are an attractive class of potential molecular tags for magnetic resonance imaging owing to their biocompatibility and ease of incorporation into a large variety of molecules. In their Communication (DOI: 10.1002/anie.201704970) W. S. Warren, S. J. Malcolmson, Q. Wang, and co-workers show with a 15N2-diazirine-containing choline derivative that 15N2-diazirine motifs are capable of supporting long-lasting polarization by the simple SABRE-SHEATH hyperpolarization method making then promising as tags for NMR/MRI imaging.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707296

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