Manganese-Based Layered Double Hydroxide Nanoparticles as a T1-MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity

5 years ago

Manganese-Based Layered Double Hydroxide Nanoparticles as a T1-MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity

Zhi Ping Xu, Zi Gu, Nyoman Kurniawan, Weiyu Chen, Bei Li

Recently, Mn(II)-containing nanoparticles have been explored widely as an attractive alternative to Gd(III)-based T1-weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, as far as it is known, no Mn-based MRI CAs have been reported to sensitively respond to a very weakly acidic environment (pH 6.5–7.0, i.e., the pH range in a tumor microenvironment) with satisfactory imaging performance. Here, recently devised pH-ultrasensitive Mn-based layered double hydroxide (Mn-LDH) nanoparticles with superb longitudinal relaxivity (9.48 mm−1 s−1 at pH 5.0 and 6.82 mm−1 s−1 at pH 7.0 vs 1.16 mm−1 s−1 at pH 7.4) are reported, which may result from the unique microstructure of Mn ions in Mn-LDH, as demonstrated by extended X-ray absorption fine structure. Further in vivo imaging reveals that Mn-LDH nanoparticles show clear MR imaging for tumor tissues in mice for 2 d post intravenous injection. Thus, this novel Mn-doped LDH nanomaterial, together with already demonstrated capacity for drug and gene delivery, is a very potential theranostic agent for cancer diagnosis and treatment. Novel Mn-based layered double hydroxide (Mn-LDH) nanoparticles show excellent magnetic resonance imaging capacity with outstanding pH-ultrasensitivity at pH 7.4–6.5 and superb longitudinal relaxivity. These Mn-LDH nanoparticles are able to clearly image tumor tissue for 2 d in vivo. Together with demonstrated capacity for drug and gene delivery, Mn-LDH nanomaterials are potential theranostic agents for cancer treatment.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adma.201700373