4 years ago

Total Synthesis and Structural Assignment of Curvicollide C

Total Synthesis and Structural Assignment of Curvicollide C
Valeska von Kiedrowski, Martin Hiersemann, Florian Quentin
The first total synthesis of (+)-curvicollide C has been accomplished. Cross-metathesis and Julia–Kocienski olefination were instrumental in the synthesis of 1,3-diene segments and allowed for a ternary-convergent synthetic design. A full structural assignment is proposed for (−)-curvicollide C, a uniquely structured polyketide of fungal origin.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02126

DOI: 10.1021/acs.orglett.7b02126

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