Small
Small
5 years ago

Cancer Therapy: TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance (Small 29/2017)

Cancer Therapy: TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance (Small 29/2017)
Lv Xu, Wei Tao, Yixiong Zuo, Nansha Gao, Xudong Zhang, Gan Liu, Lin Mei, Chaoyu Liang, Xiaowei Zeng, Lingyan Luo, Xusheng Wang, Wei Cheng
In article number 1700623, by Xiaowei Zeng, Lin Mei, and co-workers, a pH-sensitive drug delivery vehicle based on TPGS-modified polydopamine-coated mesoporous silica nanoparticles is developed. This nanoparticle shows good performance inhibiting cancer multidrug resistance by suppressing the function of the P-glycoprotein. This drug-loaded delivery platform exhibits significantly superior antitumor efficacy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201770160

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