Chemistry - A European Journal
Chemistry - A European Journal
4 years ago

A Target-Directed Chemo-Photothermal System Based on Transferrin and Copolymer-Modified MoS2 Nanoplates with pH-Activated Drug Release

A Target-Directed Chemo-Photothermal System Based on Transferrin and Copolymer-Modified MoS2 Nanoplates with pH-Activated Drug Release
Aihua Li, Zichao Li, Wenxue Tian, Aitang Zhang, Mengli Liu, Wei Zhao, Yong Sun, Jingquan Liu, Chen Wei
Molybdenum disulfide (MoS2) nanosheets have attracted significant attention due to their photothermal properties, but the poor solubility and colloidal stability limited their further application in biomedical field. Here, we report a targeted photothermal controllable nanocarrier consisting of MoS2 nanosheets modified with block copolymer P(OEG-A)-b-P(VBA-co-KH570) and targeting ligand transferrin. P(OEG-A)-b-P(VBA-co-KH570) is synthesized by RAFT polymerization and utilized not only to improve the solubility of MoS2 nanosheets but also efficiently load the anti-cancer drug doxorubicin (DOX) through an acid-cleavable Schiff base linker. Thiol-functionalized transferrin (Tf-SH) is anchored onto the surface of MoS2 nanosheets by the formation of disulfide bonds, which could further enhance the cellular uptake of DOX and MoS2 to HepG2 cells for high-efficiency synergetic therapy. The drug release experiments exhibited the minimal release of DOX at room temperature and neutral pH, and the maximal drug release of 53 % at acidic tumor pH and hyperthermia condition after 48 h. In addition, the DOX-loaded, Tf-SH and P(OEG-A)-b-P(VBA-co-KH570) modified MoS2 (DOX-POVK-MoS2-Tf) showed better a therapeutic effect than DOX-POVK-MoS2 and POVK-MoS2, probably owing to the combined effects of target-directed uptake, acid-triggered drug release, and NIR induced localized heating, which suggest the designed MoS2 nanocarriers are promising for applications in multi-modal cancer therapy. A target-directed chemo-photothermal therapy system with pH-activated drug release behavior is prepared based on MoS2 nanoplates modified with transferrin and copolymer P(OEG-A)-b-P(VBA-co-KH570). The as-prepared DOX-POVK-MoS2-Tf nanocomposites exhibit well a therapeutic effect to HepG2 cells owing to the combined effects of target-directed uptake, acid-triggered drug release and NIR-induced localized heating, which suggest the designed MoS2 nanocarriers are promising for active-targeting chemo-photothermal synergetic therapy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701916

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.