3 years ago

Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK

Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK
Jonathan M. White, Paul S. Donnelly, John A. Karas, Uwe Ackermann, Michelle T. Ma, Andrea J. North, Philip J. Blower
New pyridylthiosemicarbazide ligands conjugated to the tumor targeting peptides octreotate and cyclic-RGD peptides were used to form {M═O}3+ complexes (where M = Tc or Re) that feature two targeting peptides attached to the single metal ion. These modified “HYNIC” ligands are capable of forming well-defined rhenium and technetium complexes offering the possibility of using radionuclides of technetium and rhenium as imaging and therapeutic matched pairs.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01247

DOI: 10.1021/acs.inorgchem.7b01247

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