Organic Letters
Organic Letters
5 years ago

Hydrophobic α,α-Disubstituted Disilylated TESDpg Induces Incipient 310-Helix in Short Tripeptide Sequence

Hydrophobic α,α-Disubstituted Disilylated TESDpg Induces Incipient 310-Helix in Short Tripeptide Sequence
Roberto Fanelli, Jean Martinez, Dorothée Berthomieu, Claude Didierjean, Abdelatif Doudouh, Florine Cavelier, Aurélien Lebrun
To evaluate the contribution of triethylsilyl α,α-di-n-propylglycine, namely TESDpg, to induce a defined secondary structure, we have prepared model tripeptides in which TESDpg was inserted in three different positions. Studies in solid state and in solution with adapted techniques showed that TESDpg was able to induce a nascent 310 helix in both crystal and solution states.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01172

DOI: 10.1021/acs.orglett.7b01172

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