5 years ago

Novel Fluorescent Microemulsion: Probing Properties, Investigating Mechanism, and Unveiling Potential Application

Novel Fluorescent Microemulsion: Probing Properties, Investigating Mechanism, and Unveiling Potential Application
Zhanzhong Wang, Leping Dang, Mengna Hou, Tiankuo Liu, Yun Guo
Nanoscale microemulsions have been utilized as delivery carriers for nutraceuticals and active biological drugs. Herein, we designed and synthesized a novel oil in water (O/W) fluorescent microemulsion based on isoamyl acetate, polyoxyethylene castor oil EL (CrEL), and water. The microemulsion emitted bright blue fluorescence, thus exhibiting its potential for active drug detection with label-free strategy. The microemulsion exhibited excitation-dependent emission and distinct red shift with longer excitation wavelengths. Lifetime and quantum yield of fluorescent microemulsion were 2.831 ns and 5.0%, respectively. An excellent fluorescent stability of the microemulsion was confirmed by altering pH, ionic strength, temperature, and time. Moreover, we proposed a probable mechanism of fluorochromic phenomenon, in connection with the aromatic ring structure of polyoxyethylene ether substituent in CrEL. Based on our findings, we concluded that this new fluorescent microemulsion is a promising drug carrier that can facilitate active drug detection with a label-free strategy. Although further research is required to understand the exact mechanism behind its fluorescence property, this work provided valuable guidance to develop new biosensors based on fluorescent microemulsion.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b05819

DOI: 10.1021/acsami.7b05819

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