5 years ago

Targeted Protein Detection Using an All-in-One Mass Spectrometry Cartridge

Targeted Protein Detection Using an All-in-One Mass Spectrometry Cartridge
Chengsen Zhang, Nicholas E. Manicke, Trevor Glaros
We developed a simple 3D printed cartridge for mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modifications (PTMs). The cartridge uses an integrated antibody enrichment column to preconcentrate the protein target as well as a novel built-in substrate to ionize the protein targets for MS detection. We show several examples of using this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b05571

DOI: 10.1021/jacs.7b05571

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