4 years ago

Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide

Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide
Congcong Chen, Caicai Meng, Xi Chen, Zhipeng Han, Hongzhi Cao, Tian Gao, Fengshan Wang, Peng Peng

A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.

Publisher URL: http://www.tandfonline.com/doi/full/10.1080/07328303.2017.1315123

DOI: 10.1080/07328303.2017.1315123

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