Chemistry of Materials
Chemistry of Materials
5 years ago

Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity
Amir Ata Saei, Mahtab Asadian, Alireza Mashaghi, Mahdieh Yazdani, Zahra Bakhtiary, Vahid Serpooshan, Erik C. Dreaden, Samuel E. Lohse, Morteza Mahmoudi, Mahdi Ghavami, Samaneh Mashaghi
Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.

Publisher URL: http://dx.doi.org/10.1021/acs.chemmater.7b01979

DOI: 10.1021/acs.chemmater.7b01979

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