3 years ago

C1-Symmetric Chiral Iodoarenes Bearing Triazoles – Modular Synthesis and Application in Enantioselective Spirocyclizations

C1-Symmetric Chiral Iodoarenes Bearing Triazoles – Modular Synthesis and Application in Enantioselective Spirocyclizations
Christian Hepel, Boris J. Nachtsheim, Miquel A. Pericàs, Caeciliea Maichle-Mössmer
The inside cover picture, provided by Pericàs and Nachtsheim, illustrates the development of novel C1-symmetric iodoarenes as precursors for chiral aryl-λ3-iodanes. The synthesis of these structures is highly modular and allows easy modification on all major substituents, namely the arene, the alkyl ether and the terminal triazole. This is not only the first example for a triazole-based chiral iodoarene but also the so far most efficient C1-symmetric catalyst for the oxidative enantioselective spirocyclization of 1-naphtholcarboxylic acids to spirolactones. Details can be found in the full paper on pages xxxx–xxxx (C. Hempel, C. Maichle-Moessmer, M. A. Pericàs, B. J. Nachtsheim, Adv. Synth. Catal. 2017, 359, xxxx–xxxx; DOI: 10.1002/adsc.201700246).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700892

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