3 years ago

Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study

Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study
We incorporated bovine serum albumin (BSA)-functionalized graphene in poly(ethylene glycol) diacrylate (PEG) hydrogels. The graphene alignment in PEG hydrogels was changed using dielectrophoresis (DEP) forces. Effect of graphene concentration (2.55 and 5.1 mg/mL) and alignment (vertical and horizontal) on electrical and mechanical properties of hybrid graphene-PEG gels was evaluated. In addition, the molecular interaction of BSA peptides with graphene in the presence and absence of an electric field was assessed. The incorporation of graphene in PEG improved mechanical properties of hybrid gels. Dielectrophoretically aligned graphene-PEG hydrogels showed an anisotropic electrical conductivity. Young's modulus of 5.1 mg/mL graphene-PEG was almost three times higher than that of pristine PEG. Viability and proliferation of mouse embryonic stem cells on graphene-PEG gels were comparable with control PEG hydrogels. Ab initio calculations showed longer peptides had higher binding affinity towards graphene and caused a change in dipole moment due to the presence of electric field. The electric field also expanded graphene and peptide chains, which confirms the graphene alignment using DEP forces. Hybrid aligned graphene-PEG hydrogels may serve as functional biomaterials to engineer biological tissues and fabricate biomedical devices.

Publisher URL: www.sciencedirect.com/science

DOI: S0008622317307649

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.