Organic Letters
Organic Letters
5 years ago

Reductive CO2 Fixation via Tandem C–C and C–N Bond Formation: Synthesis of Spiro-indolepyrrolidines

Reductive CO2 Fixation via Tandem C–C and C–N Bond Formation: Synthesis of Spiro-indolepyrrolidines
Ji-Bao Xia, Yazhou Wang, Hui Han, Dao-Yong Zhu, Lei Fang
We describe herein a tandem C–C and C–N bond-forming reaction in the reductive functionalization of CO2, an abundant and cheap C1 chemical feedstock. This catalytic metal-free CO2 fixation afforded spiro-indolepyrrolidines by dearomatization of tryptamine derivatives with broad scope and good functional group tolerance under mild conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01906

DOI: 10.1021/acs.orglett.7b01906

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