3 years ago

A C–H Activation-Based Strategy for N-Amino Azaheterocycle Synthesis

A C–H Activation-Based Strategy for N-Amino Azaheterocycle Synthesis
Shan Guo, Jie Wang, Lili Wang, Jin Zhu, Kehao Chen, Pengfei Shi
A C–H activation-based strategy has been developed for the synthesis of N-amino azaheterocycles. Rh(III)-catalyzed coupling of N-Boc hydrazones/N-Boc hydrazines with diazodiesters/diazoketoesters provides convenient access to synthetically and medicinally important compounds, N-amino isoquinolin-3-ones and N-amino indoles, by harnessing N-tert-butyloxycarbonyl (N-Boc) cleavage as an adaptable reactivity pattern in distinct synthetic scenarios.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02066

DOI: 10.1021/acs.orglett.7b02066

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