3 years ago

Four Hybrid Flavan–Chalcones, Caesalpinnone A Possessing a 10,11-Dioxatricyclic [5.3.3.01,6]Tridecane-Bridged System and Caesalpinflavans A–C from Caesalpinia enneaphylla

Four Hybrid Flavan–Chalcones, Caesalpinnone A Possessing a 10,11-Dioxatricyclic [5.3.3.01,6]Tridecane-Bridged System and Caesalpinflavans A–C from Caesalpinia enneaphylla
Guang-Hui Xia, De-Wen Bi, Lan-Jun Zhang, Li-Qin Wang, Liu Yang, Wei-Hua Mu, Xiao-Nian Li, Yuan-Ping Li, Xue-Song Liang, Jiangmiao Hu
Caesalpinnone A (1), an unprecedented hybrid of flavan and chalcone, possessing a 10,11-dioxatricyclic [5.3.3.01,6]tridecane-bridged system, and caesalpinflavans A–C (24), three new hybrid flavan–chalcones, were isolated from the twigs and leaves of Caesalpinia enneaphylla. Their structures were elucidated by a combination of spectroscopic analyses and single-crystal X-ray diffraction. Caesalpinnone A showed the highest cytotoxicity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines with an IC50 in the range of 0.54–0.87 μM.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01955

DOI: 10.1021/acs.orglett.7b01955

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.