5 years ago

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes [Neuroscience]

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes [Neuroscience]
Sarasa Tohyama, David Yachnin, Lindsey Gerstein, Christos G. Gkogkas, Shannon Tansley, Arkady Khoutorsky, Alexander H. Tuttle, Melissa Sukosd, Claire M. Chan, Philip Leger, Kimberly Dossett, Isabelle Groves, Jeffrey S. Mogil, Sioui Maldonado-Bouchard, Oliver M. Hardt, Jean-Sebastien Austin, Rebecca Pearl, Nahum Sonenberg, Liane Stein, Tine Pooters, Hayley Crawhall-Duk, Loren J. Martin

Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with “autistic-like” phenotypes (Fmr1−/y and Eif4e Ser209Ala) displayed significantly decreased cooccupancy.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.