3 years ago

Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source

Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source
Xue Lv, Lihong Hu, Yinan Zhang, Guanglong Sun, Min Lei
A facile and practical method for the synthesis of aromatic aldehydes by palladium-catalyzed reductive carbonylation starting from aryl iodides and HCOOH is described. Compared to the known formylation procedure, HCOOH serves not only as the most convenient and environmental-friendly C1 source but also as the reviving agent in the reductive elimination process of a Pd-catalyst. Furthermore, this procedure is also applied successfully to the modification of natural products, such as vindoline, tabersonin, and vincamine, to obtain the corresponding products in good yields.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01882

DOI: 10.1021/acs.orglett.7b01882

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