5 years ago

Copper-Catalyzed C–H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes

Copper-Catalyzed C–H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes
Xiangyang Tang, Guangwei Wang, Minjie Guo, Dingsheng Zhu, Xiaoyang Wang, Jing Liu, Shuang Zhao
A general and facile synthetic method for C(sp2)–H difluoroalkylations and perfluoroalkylations of alkenes and (hetero)arenes with commercially available fluoroalkyl halides has been developed with a copper-amine catalyst system. This method is characterized by high yields, mild reaction conditions, low-cost catalyst, broad substrate scope, and excellent functional group compatibility, therefore providing a convenient synthetic strategy toward various difluoroalkyl- and perfluoroalkyl-substituted alkenes and (hetero)arenes.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01712

DOI: 10.1021/acs.orglett.7b01712

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