3 years ago

Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (−)-Fasicularin and (−)-Lepadiformine A

Cross-Metathesis Approach to the Tricyclic Marine Alkaloids (−)-Fasicularin and (−)-Lepadiformine A
W. Roy Jackson, Andrea J. Robinson, Zhen J. Wang, James Burnley
A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted α-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (−)-fasicularin 2 and a pro-forma synthesis of (−)-lepadiformine A 1.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01135

DOI: 10.1021/acs.joc.7b01135

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