3 years ago

Tunable, Chemo- and Site-Selective Nitrene Transfer Reactions through the Rational Design of Silver(I) Catalysts

Tunable, Chemo- and Site-Selective Nitrene Transfer Reactions through the Rational Design of Silver(I) Catalysts
Juliet M. Alderson, Jennifer M. Schomaker, Joshua R. Corbin
Carbon–nitrogen (C–N) bonds are ubiquitous in pharmaceuticals, agrochemicals, diverse bioactive natural products, and ligands for transition metal catalysts. An effective strategy for introducing a new C–N bond into a molecule is through transition metal-catalyzed nitrene transfer chemistry. In these reactions, a metal–supported nitrene can either add across a C═C bond to form an aziridine or insert into a C–H bond to furnish the corresponding amine. Typical catalysts for nitrene transfer include Rh2Ln and Ru2Ln complexes supported by bridging carboxylate and related ligands, as well as complexes based on Cu, Co, Ir, Fe, and Mn supported by porphyrins and related ligands.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00178

DOI: 10.1021/acs.accounts.7b00178

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